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Papers of the Week

2022 Aug 11

Am J Obstet Gynecol MFM

Trends in Gestational Age at Delivery for Intrahepatic Cholestasis of Pregnancy and Adoption of Society Guidelines.


Lagon EP, Soffer MD, James KE, Mecklai K, Li DK, Schaefer EA, Duzyj CM
Am J Obstet Gynecol MFM. 2022 Aug 11:100709.
PMID: 35964933.


Intrahepatic cholestasis of pregnancy is associated with significant risk of stillbirth which contributes to variation in clinical management. Recent Society for Maternal-Fetal Medicine guidance recommends 36 week delivery for patients with serum bile acids >100 umol/L, consideration for delivery between 36-39 weeks stratified by bile acid level, and against preterm delivery for those with clinical features of cholestasis without bile acid elevation.