I am a
Home I AM A Search Login

Papers of the Week


Front Neurol


Case report: First case of neuromelioidosis in Europe: CNS infection caused by .


Dimitriou NG, Flüh G, Zange S, Aytulun A, Turowski B, Hartung H-P, Meuth SG, Gliem M
Front Neurol. 2022; 13:899396.
PMID: 35968288.


Neuromelioidosis is a rare CNS infection caused by and is characterized by high morbidity and mortality. Our report presents the diagnostic and therapeutic approach of the first case of neuromelioidosis confirmed in Europe. A 47-year-old man with a medical history of recurrent otitis with otorrhea and fever after tympanoplasty and radical cavity revision operation on the left ear was admitted with headache, decreased level of consciousness, dysarthria, left-sided hemiparesis, and urinary incontinence. After extensive investigations including MRI, microbiological, serological, and CSF analyses, and, ultimately, brain biopsy, a diagnosis of neuromelioidosis was established. Despite antibiotic treatment, the patient showed no clinical improvement and remained in a severely compromised neurological state under mandatory mechanical ventilation. Neuromelioidosis can pose a diagnostic challenge requiring an extensive diagnostic evaluation because of its uncommon clinical and radiological presentations.