I am a
Home I AM A Search Login

Papers of the Week

2022 Aug 11

Blood Purif

Randomized Control Study on Hemoperfusion Combined with Hemodialysis versus Standard Hemodialysis: Effects on Middle-Molecular-Weight Toxins and Uremic Pruritus.


Zhao D, Wang Y, Wang Y, Jiang A, Cao N, He Y, Wang J, Guo Z Y, Liu W, Shi W, Hao L, Li J, Li W, Wang C, Wang J, Lin H, Shi W, Wang L, Jiang H, Ding G, et al.
Blood Purif. 2022 Aug 11:1-11.
PMID: 35952629.


Classic hemodialysis schedules present inadequate middle-molecular-weight toxin clearance due to limitations of membrane-based separation processes. Accumulation of uremic retention solutes may result in specific symptoms (e.g., pruritus) and may affect clinical outcome and patient's quality of life. Hemoperfusion (HP) is a blood purification modality based on adsorption that can overcome such limitations, and thus, it may be interesting to test the efficacy of at least one session per week of HP combined with hemodialysis. This is a randomized, open-label trial, controlled, multicenter clinical study to investigate the effect of long-term HP combined with hemodialysis on middle-molecular-weight toxins and uremic pruritus in maintenance hemodialysis (MHD) patients.