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Papers of the Week

2022 Sep-Oct

J Oral Biol Craniofac Res



Nerve growth factor and S100B: Molecular marker of neuroregeneration after injection of freeze-Dried platelet rich plasma.


Radithia D, Soebadi B, Parmadiati A E, Winias S
J Oral Biol Craniofac Res. 2022 Sep-Oct; 12(5):570-574.
PMID: 35957941.


Chronic orofacial pain is associated with nerve tissues damage. Pharmacological therapy has limited therapeutic results because it is generally only symptomatic treatment. Neuroregeneration is a process which is needed to repair damaged of nerve tissue through healing or regrowth of nerve tissue. The survival of nerve cells need neurotrophic factors including Nerve Growth Factor (NGF) and S100B. High platelet concentrations in Platelet Rich Plasma contain of many trophic factors which play an important role in peripheral nerve regeneration following nerve injury. The aim of the present study is to analyze the increased expression of NGF and S100B following injection of Freeze-Dried Platelet Rich Plasma (FD-PRP) on axonotmesis injury.