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Papers of the Week

Papers: 6 Aug 2022 - 12 Aug 2022

Pharmacology/Drug Development

2022 Aug 10

Jpn J Clin Oncol

Rapid titration with oral sustained-release morphine plus subcutaneous morphine in a multi-center, randomized control study of cancer patients with moderate to severe cancer pain.


Sun Y, Wei H, Yu M, Zheng R, Li J, Fu Y, Zheng Y, Zhang X, Shou F, Zhou J, Yao W, Chen P, Liu D, Jia Y, Fu Y, Wang Y, Zhu J
Jpn J Clin Oncol. 2022 Aug 10.
PMID: 35946332.


Pain is one of the most common concomitant symptoms among cancer patients. Pharmacologic agents are regarded as a cornerstone of cancer pain management. 'Dose titration' with short-acting morphine is widely accepted. Such a titration method is very complicated. The analgesic background establishment is often delayed. Titration based on sustained-release opioids is also recommended, but the onset of analgesic effect requires hours, whereas the rescue analgesia is always needed. This study evaluated the optimized morphine titration scheme with a simultaneous combination of sustained-release morphine and subcutaneous morphine.