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Papers of the Week

2022 Aug 09

Cochrane Database Syst Rev


Immunity after COVID-19 vaccination in people with higher risk of compromised immune status: a scoping review.


Kreuzberger N, Hirsch C, Andreas M, Böhm L, Bröckelmann PJ, Di Cristanziano V, Golinski M, Hausinger R I, Mellinghoff S, Lange B, Lischetzki T, Kappler V, Mikolajewska A, Monsef I, Park Y S, Piechotta V, Schmaderer C, Stegemann M, Vanshylla K, Weber F, et al.
Cochrane Database Syst Rev. 2022 Aug 09; 8:CD015021.
PMID: 35943061.


High efficacy in terms of protection from severe COVID-19 has been demonstrated for several SARS-CoV-2 vaccines. However, patients with compromised immune status develop a weaker and less stable immune response to vaccination. Strong immune response may not always translate into clinical benefit, therefore it is important to synthesise evidence on modified schemes and types of vaccination in these population subgroups for guiding health decisions. As the literature on COVID-19 vaccines continues to expand, we aimed to scope the literature on multiple subgroups to subsequently decide on the most relevant research questions to be answered by systematic reviews.