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Papers of the Week

Papers: 6 Aug 2022 - 12 Aug 2022

Animal Studies, Pharmacology/Drug Development

2022 Aug 04


Editor's Pick

Gut Microbiota Alter Visceral Pain Sensation and Inflammation via Modulation of Synthesis of Resolvin D1 in Colonic Tuft Cells.


Grabauskas G, Gao J, Wu X, Zhou S-Y, Turgeon DK, Owyang C
Gastroenterology. 2022 Aug 04.
PMID: 35934059.


Visceral hypersensitivity and low grade mucosal inflammation are frequently observed in a subpopulation of irritable bowel syndrome (IBS) patients. The responsible mechanism is unclear. Resolvins are a novel class of anti-inflammatory lipid mediators that regulate resolution of inflammation and pain. We hypothesize that resolvin D1 (RvD1) synthesis is reduced in IBS-D colonic mucosa and contribute to the development of visceral hypersensitivity.