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Papers of the Week


Papers: 23 Jul 2022 - 29 Jul 2022


2022 Jul 07


Viruses


14


7

The Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) and PainDETECT Questionnaires in COVID-19 Survivors with Post-COVID Pain.

Authors

Fernández-de-Las-Peñas C, Valera-Calero J A, Herrero-Montes M, Del-Valle-Loarte P, Rodríguez-Rosado R, Ferrer-Pargada D, Arendt-Nielsen L, Parás-Bravo P
Viruses. 2022 Jul 07; 14(7).
PMID: 35891466.

Abstract

This study aimed to analyze correlations between Self-Report Leeds Assessment of Neuropathic Symptoms (S-LANSS) and PainDETECT with proxies of sensitization, pain-related, or psychological/cognitive variables in coronavirus disease, 2019 (COVID-19) survivors exhibiting post-COVID pain. Demographic, clinical, psychological, cognitive, sensitization-associated symptoms, and health-related quality of life were collected in 146 survivors with post-COVID pain. The PainDETECT and S-LANSS questionnaires were used for assessing neuropathic pain-related symptoms. Patients were assessed with a mean of 18.8 (SD 1.8) months after hospitalization. Both questionnaires were positively associated with pain intensity ( < 0.05), anxiety (PainDETECT < 0.05; S-LANSS < 0.01), sensitization-associated symptoms ( < 0.01), catastrophism ( < 0.01), and kinesiophobia ( < 0.01) and negatively associated with quality of life (PainDETECT < 0.05; S-LANSS < 0.01). Depressive levels were associated with S-LANSS ( < 0.05) but not with PainDETECT. The stepwise regression analyses revealed that 47.2% of S-LANSS was explained by PainDETECT (44.6%), post-COVID pain symptoms duration (1.7%), and weight (1.1%), whereas 51.2% of PainDETECT was explained by S-LANSS (44.6%), sensitization-associated symptoms (5.4%), and anxiety levels (1.2%). A good convergent association between S-LANSS and PainDETECT was found. Additionally, S-LANSS was associated with symptom duration and weight whereas PainDETECT was associated with sensitization-associated symptoms and anxiety levels, suggesting that the two questionnaires evaluate different aspects of the neuropathic pain spectrum in post-COVID pain patients.