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Papers of the Week

2022 Jun 13

Am J Vet Res



Long-acting injectable methadone (methadone-fluconazole) provides safe and effective postoperative analgesia in a randomized clinical trial for dogs undergoing soft tissue surgery.


Bieberly ZD, KuKanich B, KuKanich KS, Berke KA, Klocke EE, Upchurch DA, Comroe AJ, Jugan MC, Mason DE, Orchard RJ, Klutzke JB, Fitzgerald AH, Woodruff K
Am J Vet Res. 2022 Jun 13; 83(8).
PMID: 35895789.


To assess the pharmacokinetics, clinical efficacy, and adverse effects of injectable methadone with the pharmacokinetic enhancer fluconazole (methadone-fluconazole), compared with the standard formulation of injectable methadone, in dogs after ovariohysterectomy. We hypothesized that 2 doses of methadone-fluconazole would provide 24 hours of postoperative analgesia.