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Papers of the Week


2022 Jun 13


Am J Vet Res


83


8

Long-acting injectable methadone (methadone-fluconazole) provides safe and effective postoperative analgesia in a randomized clinical trial for dogs undergoing soft tissue surgery.

Authors

Bieberly ZD, KuKanich B, KuKanich KS, Berke KA, Klocke EE, Upchurch DA, Comroe AJ, Jugan MC, Mason DE, Orchard RJ, Klutzke JB, Fitzgerald AH, Woodruff K
Am J Vet Res. 2022 Jun 13; 83(8).
PMID: 35895789.

Abstract

To assess the pharmacokinetics, clinical efficacy, and adverse effects of injectable methadone with the pharmacokinetic enhancer fluconazole (methadone-fluconazole), compared with the standard formulation of injectable methadone, in dogs after ovariohysterectomy. We hypothesized that 2 doses of methadone-fluconazole would provide 24 hours of postoperative analgesia.