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2022 Jul 26
Neuropathol Appl Neurobiol
Abundant recent evidence has shown that 3-phosphoinositide-dependent protein kinase 1 (PDK1) is activated in Alzheimer's disease (AD). However, it remains unknown whether inhibition of PDK1 in neurons may affect AD-like pathology in animal models of AD. Here we aim to examine the effects of specific inactivation of neuronal PDK1 on pathology and behaviour in 5×FAD mice, and to identify the underlying molecular mechanisms.