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Papers of the Week

2022 Jul 26

Neuropathol Appl Neurobiol

Genetic Inhibition of PDK1 Robustly Reduces Plaque Deposition and Ameliorates Gliosis in the 5×FAD Mouse Model of Alzheimer’s Disease.


Ye X, Chen L, Wang H, Peng S, Liu M, Yao L, Zhang Y, Shi Y S, Cao Y, Yang J-J, Chen G
Neuropathol Appl Neurobiol. 2022 Jul 26:e12839.
PMID: 35881686.


Abundant recent evidence has shown that 3-phosphoinositide-dependent protein kinase 1 (PDK1) is activated in Alzheimer's disease (AD). However, it remains unknown whether inhibition of PDK1 in neurons may affect AD-like pathology in animal models of AD. Here we aim to examine the effects of specific inactivation of neuronal PDK1 on pathology and behaviour in 5×FAD mice, and to identify the underlying molecular mechanisms.