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Orthostatic hypotension as the initial presentation of disseminated cryptococcosis in a kidney transplant recipient.


Solid organ transplant recipients are immunocompromised and at risk for invasive viral, fungal, and bacterial pathogens. is the third most common invasive fungal infection in transplant recipients, and the clinical presentation of Cryptococcus neoformans infection can vary widely. Cryptococcal disease can affect the brain, lungs, skin, or vasculature, and it is frequently disseminated. Meningitis typically presents with fever, headache, and altered mental status. Solid organ transplant recipients with cryptococcosis tend to have poorer outcomes than HIV patients with cryptococcosis.