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Papers of the Week
Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain.
Authors
Abstract
The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator. However, its involvement in pathological pain is poorly understood. We studied the contribution of AM to chronic neuropathic pain in the spinal nerve ligation (SNL) model.