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Papers of the Week

2022 Jan-Dec

Integr Cancer Ther


Prevention of Bortezomib-Induced Peripheral Neuropathy in Newly Multiple Myeloma Patients Using Nervonic Acid, Curcuma Rizoma, and L-Arginine Compound: A Pilot Study.


Maschio M, Maialetti A, Marchesi F, Gumenyuk S, Pisani F, Papa E, Galiè E, Koudriavtseva T, Graziano G, Giannarelli D, Mengarelli A
Integr Cancer Ther. 2022 Jan-Dec; 21:15347354221114142.
PMID: 35866451.


This is a phase II pilot study to evaluate the efficacy of a nutraceutical compound composed of nervonic acid, curcuma rizoma, and l-Arginine to prevent the onset of bortezomib-induced peripheral neuropathy (BIPN) in 16 newly diagnosed multiple myeloma (MM) patients treated with bortezomib (BTZ) over 6 months.