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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis.

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2022 Jul 19


J Surg Res


http://www.ncbi.nlm.nih.gov/pubmed/35868036?dopt=Abstract


279

Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis.

Authors

Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis.
Tsai H-J, Chian C-F, Shih C-C, Chen S-J, Liaw W-J, Huang H-C, Tsao C-M, Wu C-C
J Surg Res. 2022 Jul 19; 279:526-532.
PMID: 35868036.

Abstract

Sepsis and related complications lead to high morbidity and mortality in humans and animals. Olmesartan medoxomil (OLM), a nonpeptide angiotensin II type 1 receptor blocker, has antiinflammatory and antioxidative effects in various experimental animal models. The present study aimed to investigate whether OLM protects against sepsis in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).
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