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Papers of the Week

2022 Jul 18

BMJ Open



Effect of epidural spinal cord stimulation after chronic spinal cord injury on volitional movement and cardiovascular function: study protocol for the phase II open label controlled E-STAND trial.


Darrow DP, Balser D Y, Freeman D, Pelrine E, Krassioukov A, Phillips A, Netoff T, Parr A, Samadani U
BMJ Open. 2022 Jul 18; 12(7):e059126.
PMID: 35851008.


Spinal cord injury (SCI) leads to significant changes in morbidity, mortality and quality of life (QOL). Currently, there are no effective therapies to restore function after chronic SCI. Preliminary studies have indicated that epidural spinal cord stimulation (eSCS) is a promising therapy to improve motor control and autonomic function for patients with chronic SCI. The aim of this study is to assess the effects of tonic eSCS after chronic SCI on quantitative outcomes of volitional movement and cardiovascular function. Our secondary objective is to optimise spinal cord stimulation parameters for volitional movement.