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Papers of the Week

2022 Jul 21

Expert Opin Drug Saf

Safety and tolerability of spesolimab in patients with ulcerative colitis.


Ferrante M, Irving PM, Selinger CP, D'haens G, Kuehbacher T, Seidler U, Gropper S, Haeufel T, Forgia S, Danese S, Klaus J, Feagan BG
Expert Opin Drug Saf. 2022 Jul 21.
PMID: 35861588.


Interleukin (IL)-36 signaling has been shown to be increased in ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL-36 pathway.