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Papers of the Week


2022 Jul 21


Expert Opin Drug Saf

Safety and tolerability of spesolimab in patients with ulcerative colitis.

Authors

Ferrante M, Irving PM, Selinger CP, D'haens G, Kuehbacher T, Seidler U, Gropper S, Haeufel T, Forgia S, Danese S, Klaus J, Feagan BG
Expert Opin Drug Saf. 2022 Jul 21.
PMID: 35861588.

Abstract

Interleukin (IL)-36 signaling has been shown to be increased in ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL-36 pathway.