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Papers of the Week

2022 Jul 15

Circ Res

Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow.


Zhou J-J, Shao J-Y, Chen S-R, Pan H-L
Circ Res. 2022 Jul 15:101161CIRCRESAHA122320976.
PMID: 35862168.


Hypertension is a common and serious adverse effect of calcineurin inhibitors, including cyclosporine and tacrolimus (FK506). Although increased sympathetic nerve discharges are associated with calcineurin inhibitor-induced hypertension, the sources of excess sympathetic outflow and underlying mechanisms remain elusive. Calcineurin (protein phosphatase-2B) is broadly expressed in the brain, including the paraventricular nuclear (PVN) of the hypothalamus, which is critically involved in regulating sympathetic vasomotor tone.