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Papers of the Week

Papers: 16 Jul 2022 - 22 Jul 2022


Human Studies

2022 Jul 20

Eur J Pain

Conditioned pain modulation and offset analgesia: Influence of sex, sex hormone levels and menstrual cycle on the magnitude and retest reliability in healthy participants.



Conditioned Pain Modulation (CPM) and offset analgesia quantify impairment of endogenous pain modulation, but magnitude and reliability vary broadly between studies, indicating influencing factors that are not currently controlled for. The aim of this study was to quantify magnitude and retest reliability of CPM and offset analgesia in healthy participants, whilst investigating the influence of sex and sex hormone levels.