I am a
Home I AM A Search Login

Papers of the Week


J Inflamm Res


Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats.


Awad-Igbaria Y, Dadon S, Shamir A, Livoff A, Shlapobersky M, Bornstein J, Palzur E
J Inflamm Res. 2022; 15:3901-3923.
PMID: 35845089.


Provoked vulvodynia (PV) is the main cause of vulvar pain and dyspareunia. The etiology of PV has not yet been elucidated. However, PV is associated with a history of recurrent inflammation, and its often accompanied by increases in the numbers of mast cells (MCs) and sensory hyperinnervation in the vulva. Therefore, this study aimed to examine the role of MCs and the early inflammatory events in the development of chronic vulvar pain in a rat model of PV.