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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis.

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2022 Jul 18


Immunopharmacol Immunotoxicol


http://www.ncbi.nlm.nih.gov/pubmed/35848944?dopt=Abstract

Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis.

Authors

Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis.
Wang D, Li S, Ma X, Chen X, Tian X, Li X, Chen L, Kang Q, Wang X, Jin P, Lu X, Fu Y, Li J, Sheng J
Immunopharmacol Immunotoxicol. 2022 Jul 18:1-38.
PMID: 35848944.

Abstract

Opioid prescription for inflammatory bowel disease (IBD)-related pain is on the rise. However, the use of strong opioids can result in severe complications, and even death, in IBD patients. This study aimed to define the role of fentanyl and morphine, two representative strong opioids, in the pathogenesis of dextran sodium sulphate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid solution (TNBS)-induced colitis.
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