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Papers of the Week

Papers: 16 Jul 2022 - 22 Jul 2022

Animal Studies

2022 Jul 18

Mol Neurobiol

Hippocampal Inhibitory Synapsis Deficits Induced by α5-Containing GABA Receptors Mediate Chronic Neuropathic Pain-Related Cognitive Impairment.


Cai X, Qiu L, Wang C, Yang H, Zhou Z, Mao M, Zhu Y, Wen Y, Cai W, Zhu W, Sun J
Mol Neurobiol. 2022 Jul 18.
PMID: 35849280.


Chronic neuropathic pain often leads to cognitive impairment, but the exact mechanism remains unclear. Gamma-aminobutyric acid A receptors (GABARs) are the major inhibitory receptors in the brain, of which the α5-containing GABARs (GABARs-α5) are implicated in a range of neuropsychiatric disorders with cognitive deficits. However, whether GABARs-α5 are involved in chronic neuropathic pain-related cognitive impairment remains unknown. In this study, the rats with chronic neuropathic pain induced by right sciatic nerve ligation injury (SNI) exhibited cognitive impairment with declined spontaneous alternation in Y-maze test and discrimination index in novel object recognition test. The GABARs-α5 expressing on parvalbumin and somatostatin interneurons increased remarkably in hippocampus, resulting in decreased mean frequency of spontaneous inhibitory postsynaptic currents in hippocampal pyramidal neurons. Significantly, antagonizing the GABARs-α5 by L655708 rescued weakened inhibitory synaptic transmission and cognitive impairment induced by chronic neuropathic pain. Taken together, these data suggest that the GABARs-α5 play a crucial role in chronic neuropathic pain-induced cognitive impairment by weakening inhibitory synaptic transmission, which may provide insights into the pharmacologic treatment of chronic neuropathic pain-related cognitive impairment.