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Papers of the Week


2022 Jun 01


Anesth Prog


69


2

Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia.

Authors

Shinoda M, Nishimura A, Sugiyama E, Sato H, Iijima T
Anesth Prog. 2022 Jun 01; 69(2):3-10.
PMID: 35849812.

Abstract

Acetaminophen (APAP) is widely used as an analgesic for postoperative pain relief. However, the pharmacokinetic-pharmacodynamic (PK-PD) properties of intravenous APAP administration remain unclear. We developed a PK-PD model in adult volunteers.