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Papers of the Week

2022 Jul 16

J Orthop Surg Res



Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β.


Sun P, Xu W, Zhao X, Zhang C, Lin X, Gong M, Fu Z
J Orthop Surg Res. 2022 Jul 16; 17(1):351.
PMID: 35842709.


Osteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O) commonly have been found to have antioxidative and anti-inflammatory effects to reduce pain and improve function in knee osteoarthritis. It has been reported that reduced autophagy in chondrocytes plays an important role in the development of OA. This study aimed to probe the role of O on the autophagy in chondrocytes treated with IL-1β.