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Papers of the Week

2022 Jul

Ned Tijdschr Tandheelkd



[Oral chronic graft versus host disease, what is it and how is it treated?]


Laheij AMGA, Raber-Durlacher JE, Hazenberg MD, Schoordijk MCE, Huysmans MCDNJ, de Visscher JGAM
Ned Tijdschr Tandheelkd. 2022 Jul; 129(7-8):329-336.
PMID: 35833281.


Allogeneic stem cell transplantation can cause chronic graft versus host disease (cGVHD). A number of patients manifest cGVHD in and around the mouth. It can present itself as clinically as mucosal lesions and/or salivary gland dysfunction and/or sclerotic changes. Cheeks and tongue are most commonly affected, but the palate, gingiva and lips can also be impacted. Oral cGVHD is associated with mucosal sensitivity, pain, (severe) oral dryness, altered taste, restricted mouth opening and difficulty swallowing, all of which may contribute to a significant decrease of the patient's quality of life. Patients also run an increased risk of developing squamous cell carcinoma of the oral mucosa. The diagnosis of cGVHD is almost always based on the patient's medical history and clinical picture. Treatment of symptoms is based on the patient's problem(s). Dental professionals can provide patients with supportive preventive care aimed at reducing symptoms and preventing further deterioration of oral health.