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Papers of the Week

2022 Jun 29

Semin Arthritis Rheum


Sodium-glucose cotransporter 1 inhibition and gout: Mendelian randomisation study.


Zhao S S, Rajasundaram S, Karhunen V, Alam U, Gill D
Semin Arthritis Rheum. 2022 Jun 29; 56:152058.
PMID: 35839537.


Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce serum urate, but their efficacy depends on renal function which is often impaired in people with gout. SGLT1 is primarily expressed in the small intestine and its inhibition may be a more suitable therapeutic target. We aimed to investigate the association of genetically proxied SGLT1i with gout risk, serum urate levels and cardiovascular safety using Mendelian randomisation (MR).