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Papers of the Week

Papers: 9 Jul 2022 - 15 Jul 2022

Human Studies

2022 Jul 13


COVID-19 vaccination-triggered cluster headache episodes with frequent attacks.


Brandt RB, Ouwehand R-LH, Ferrari MD, Haan J, Fronczek R
Cephalalgia. 2022 Jul 13:3331024221113207.
PMID: 35833226.


The pathophysiology of cluster headache and how cluster episodes are triggered, are still poorly understood. Recurrent inflammation of the trigeminovascular system has been hypothesized. It was noted that some long-term attack-free cluster headache patients suddenly developed a new cluster episode shortly after COVID-19 vaccination.