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Papers of the Week

2022 Jul 07

Clin Exp Dermatol

Aquagenic Wrinkling of the Palms: Review of the Literature.


Yang K, Zhou C, Luke J
Clin Exp Dermatol. 2022 Jul 07.
PMID: 35796149.


Aquagenic wrinkling of the palms (AWP) is a rare dermatologic disease characterized by development of rapid and excessive wrinkling and edema of the palms and transient whitish or yellowish papules without erythema on the palmar surfaces after immersion in water. This phenomenon can be accompanied by pain and/or pruritus. The most common treatment of AWP involves aluminum-based topicals. This article discusses the associations, physiologic mechanisms, and treatment options of AWP.