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PLoS One



Hemodynamic and analgesic effect of intrathecal fentanyl with bupivacaine in patients undergoing elective cesarean section; a prospective cohort study.


Ebrie A M, Woldeyohanis M, Abafita B J, Ali S A, Zemedkun A, Yimer Y, Ashebir Z, Mohammed S
PLoS One. 2022; 17(7):e0268318.
PMID: 35797265.


Spinal anesthesia with bupivacaine has side effects such as hypotension, respiratory depression, vomiting, and shivering. The side effects are dose-dependent, therefore different approaches have been attempted to avoid spinal-induced complications including lowering the dose of local anesthetic and mixing it with additives like Neuraxial opioids.