I am a
Home I AM A Search Login

Papers of the Week

Papers: 9 Jul 2022 - 15 Jul 2022

2022 Jul 07

Pain Med

Capsaicin 8% Patch for Spinal Cord Injury Focal Neuropathic Pain, a Randomized Controlled Trial.


Olusanya A, Yearsley A, Brown N, Braun S, Hayes C, Rose E, Connolly B, Dicks M, Beal C, Helmonds B, Peace W, Kirkman B, Nguyen C, Erickson J, Nguyen G, Lukose E, Koek W, Nagpal AS, Trbovich M
Pain Med. 2022 Jul 07.
PMID: 35799365.


Neuropathic pain (NP) after spinal cord injury (SCI) exacerbates disability, decreases quality of life (QOL) and is often refractory to available therapies. Patients report willingness to trade potential recovery of strength, bowel, bladder, or sexual function for pain relief. One proposed mechanism causing NP is up-regulation of transient receptor potential vanilloid 1 (TRPV 1) proteins in uninjured C fibers and dorsal root ganglia causing neuronal excitability. Recent studies have found up-regulation of TRPV 1 proteins after SCI.