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Papers of the Week


2022 Jul 08


Medicine (Baltimore)


101


27

Plasma exchange treats severe intrahepatic cholestasis caused by dacomitinib: A case report.

Authors

Qiao F, Chen Q, Lu W, Fang N
Medicine (Baltimore). 2022 Jul 08; 101(27):e29629.
PMID: 35801736.

Abstract

Dacomitinib-induced liver injury is often manifested by mild elevations of transaminases and bilirubin, and severe intrahepatic cholestasis caused by dacomitinib for simultaneous taking orally cytochrome P450 2D6 (CYP2D6) competitive substrates has been rarely reported.