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Papers of the Week

Papers: 2 Jul 2022 - 8 Jul 2022

Pharmacology/Drug Development

2022 Jul 07


Galcanezumab modulates Capsaicin-induced C-fiber reactivity.


Basedau H, Oppermann T, Gundelwein Silva E, Peng K-P, May A
Cephalalgia. 2022 Jul 07:3331024221112906.
PMID: 35796521.


The vasodilatory calcitonin-gene related peptide (CGRP) is understood as pivotal mediator in migraine pathophysiology. Blocking CGRP with small molecules or monoclonal antibodies (CGRP-mAb) reduces migraine frequency. However, prescription of CGRP-mAbs is still regulated and possible predictive measures of therapeutic success would be useful.