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Papers of the Week

Papers: 2 Jul 2022 - 8 Jul 2022


2022 Jun 30

Curr Opin Neurobiol


Next generation behavioral sequencing for advancing pain quantification.


Jhumka AZ, Abdus-Saboor IJ
Curr Opin Neurobiol. 2022 Jun 30; 76:102598.
PMID: 35780688.


With symptoms such as spontaneous pain and pathologically heightened sensitivity to stimuli, chronic pain accounts for about 20% of physician visits and up to 2/3 of patients are dissatisfied with current treatments. Much of our knowledge on pain processing and analgesics has emerged from behavioral studies performed on animals presenting the same symptoms under pathological conditions. While humans can verbally describe their pain, studies on rodents have relied on behavioral assays providing non-exhaustive characterization or altering animals' original sensitivity through repetitive stimulations. The emergence of what we term "next-generation behavioral sequencing" is now permitting us to quantitatively describe behavioral features on millisecond to minutes long timescales that lie beyond easy detection with the unaided eye. Here, we summarize emerging videography and computational based behavioral approaches that have the potential to significantly improve pain research.