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Papers of the Week

Papers: 2 Jul 2022 - 8 Jul 2022

2022 Jul 05




Sickle Cell Disease: A Review.


Kavanagh PL, Fasipe TA, Wun T
JAMA. 2022 Jul 05; 328(1):57-68.
PMID: 35788790.


Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An estimated 300 000 infants are born annually worldwide with SCD. Most individuals with SCD live in sub-Saharan Africa, India, the Mediterranean, and Middle East; approximately 100 000 individuals with SCD live in the US.