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Papers of the Week

2022 Jul 04

Pharmaceut Med

Potential Channeling Bias in the Evaluation of Cardiovascular Risk: The Importance of Comparator Selection in Observational Research.


Li H, Mawanda F, Mitchell L, Zhang X, Goodloe R, Vincent M, Motsko S
Pharmaceut Med. 2022 Jul 04.
PMID: 35788962.


Comparator selection is an important consideration in the design of observational research studies that evaluate potential associations between drug therapies and adverse event risks. It can affect the validity of observational study results, and potentially impact data interpretation, regulatory decision making, and patient medication access.