Papers of the Week

Dengue is a mosquito-borne viral illness that infects humans. For the last few decades, it has been declared a global public health problem. The current study was conducted at the district headquarter hospital (DHQ) Bannu between June to September 2018 based on the seroprevalence of antibodies against dengue virus serotypes and their hematological parameters among the patients. A total of 1738 suspected individuals were diagnosed through NS1, IgG, and IgM antibodies and RT-PCR techniques. Out of all the samples, 716 (41.19%) were found to be positive for dengue. A higher infection rate was found in males (65.92%) as compared to females (34.07%). The most affected age group was 16-40 years, whereas the most affected tehsil was Bannu, where the DENV-3 serotype was prevalent. The rare serotype (DENV-4) was found in 1% of cases. Symptoms including fever (100%), myalgia (100%), headache (61.31%), vomiting (34.63%), and rashes were common among the dengue patients. However, the mild cases showed fewer clinical signs compared to the severe infected cases. The study also revealed a significant association (P<0.05) between hematological parameters and dengue infection, showing a significant decrease in TC, eosinophils, neutrophils, and platelets and a significant increase in monocytes and lymphocytes. Based on the current report, it is concluded that patients with the above symptoms and hematological changes may have increased probability of Dengue and should be kept under observation to separate dengue positive patients and enhance treatment process. This article is protected by copyright. All rights reserved.