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Papers of the Week

2021 Jun 30

Korean J Transplant



Severe anorexia and weight loss induced by tacrolimus in kidney transplant recipients.


Hwang H P, Yu H C, Chung B H, Kang K P, Kim W, Park S K, Lee S
Korean J Transplant. 2021 Jun 30; 35(2):108-111.
PMID: 35769524.


Common neuropsychiatric complications of tacrolimus include tremors, fatigue, headache, sleep disorders, paranoid reactions, and anxiety. Other, more serious complications include encephalopathy, convulsions, confusion, and coma. To our knowledge, however, severe weight loss by anorexia has not been reported as a neuropsychiatric adverse effect of tacrolimus given to adult kidney transplant recipients. In this article we present two cases of severe anorexia and weight loss associated with tacrolimus that appeared to reverse with cyclosporine.