A recent surge in monkeypox cases in non-endemic countries has been a recent concern in global health. The virus originated in Africa, and the current multi-country outbreak involves various countries in North and South America, Europe, and Australia. The virus spreads through direct contact and presents with fever, headache, muscle aches, later lymphadenopathy, and painful skin rash. The current developments include the detection of the draft genome and the approval of MVA-BN vaccine for the prevention of monkeybox. This letter presents challenges in the detection and recognition of cases along with recommendations for the early phases of the multi-country outbreak. This article is protected by copyright. All rights reserved.