I am a
Home I AM A Search Login

Papers of the Week

2022 Jun 27

Health Care Women Int

The role of female intimate hygiene practices in the management of vulvovaginal candidiasis: A randomized, controlled open-label trial.


Murina F, Lubrano C, Cappelli E, Campo M, Taraborrelli S
Health Care Women Int. 2022 Jun 27:1-12.
PMID: 35759680.


This multicenter, observational, controlled open-label trial randomized 200 women with vulvovaginal candidiasis (VVC) to: Group 1, 6-days clotrimazole 2% vaginal cream once-daily plus 15-days concomitant acid pH thymol and zinc-containing cleansing wash (SaugellaActi3) twice-daily; Group 2, 6-days clotrimazole treatment alone. In both groups, pruritus and burning VAS scores improved from baseline at Days 6, 10, and 15. On Day 10 and Day 15, the pruritus score was significantly lower in Group 1 versus Group 2 ( < 0.005 at both timepoints), suggesting acid pH thymol and zinc-containing cleansing wash ameliorates VVC-associated pruritus as part of a female hygiene regimen.