I am a
Home I AM A Search Login

Papers of the Week

2022 Jun 24

BMC Neurol



Blastic plasmacytoid dendritic cell neoplasm and cerebral toxoplasmosis: a case report.


Florescu A M, Sørensen A L T, Nielsen H V, Tolnai D, Sjö L D, Larsen K L, Al-Karagholi M A-M
BMC Neurol. 2022 Jun 24; 22(1):233.
PMID: 35751052.


The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN).  CASE PRESENTATION : A 63-year-old male presented to the department of neurology with a three-day history of rapidly progressing headache, fatigue, and confusion. Physical examination revealed multiple bruise-like skin lesions. Initial laboratory workup raised suspicion of acute leukemia, and a brain computer tomography identified several hyperdense processes. A bone marrow biopsy gave the diagnosis BPDCN, a rare and aggressive hematologic malignancy derived from plasmacytoid dendritic cells with a poor prognosis. Lumbar puncture showed not only signs of BPDCN, but also cerebral toxoplasmosis, thus providing a differential diagnosis. Despite intensive systemic and intrathecal chemotherapy, the patient died 25 days later due to multi-organ failure.