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Papers of the Week

2022 Jun 24

BMC Musculoskelet Disord



Paraspinal Muscle Health is Related to Fibrogenic, Adipogenic, and Myogenic Gene Expression in Patients with Lumbar Spine Pathology.


Anderson B, Ordaz A, Zlomislic V, Allen TR, Garfin SR, Schuepbach R, Farshad M, Schenk S, Ward SR, Shahidi B
BMC Musculoskelet Disord. 2022 Jun 24; 23(1):608.
PMID: 35739523.


Lumbar spine pathology is a common feature of lower back and/or lower extremity pain and is associated with observable degenerative changes in the lumbar paraspinal muscles that are associated with poor clinical prognosis. Despite the commonly observed phenotype of muscle degeneration in this patient population, its underlying molecular mechanisms are not well understood. The aim of this study was to investigate the relationships between groups of genes within the atrophic, myogenic, fibrogenic, adipogenic, and inflammatory pathways and multifidus muscle health in individuals undergoing surgery for lumbar spine pathology.