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Papers of the Week

2022 Jul




COVID-19-associated Isolated Cortical Vein Thrombosis: Detection of SARS-CoV-2 in CSF.


Oktar A Ç, Göçgün N, Yaşgüçlükal M A, Bayar M D, Alaçam S, Karabulut N, Duman E B, Şişman B, Baştan B, Balcı B P, Çokar Ö
Neurohospitalist. 2022 Jul; 12(3):520-523.
PMID: 35747763.


COVID-19 has been associated with central nervous system manifestations; however, cerebral venous thrombosis is rarely reported. A 34-year-old woman was admitted to the hospital with headache and recurrent seizures; she was recently discharged after COVID-19 pneumonia. Cranial magnetic resonance imaging and magnetic resonance venography showed cortical vein thrombosis in the right frontal lobe. SARS-CoV-2 RNA was detected in cerebrospinal fluid analysis. The patient was anticoagulated and put on antiepileptics. The most probable mechanism underlying the venous thrombosis is COVID-19-associated hypercoagulability. However, the relation between the viral RNA in cerebrospinal fluid analysis and the thrombosis is controversial.