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Papers of the Week

Papers: 18 Jun 2022 - 24 Jun 2022

2022 Jun 20

J Neuroinflammation



Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury.


Li Q-Y, Chen S-X, Liu J-Y, Yao P-W, Duan Y-W, Li Y-Y, Zang Y
J Neuroinflammation. 2022 Jun 20; 19(1):162.
PMID: 35725625.


Peripheral nerve inflammation or lesion can affect contralateral healthy structures, and thus result in mirror-image pain. Supraspinal structures play important roles in the occurrence of mirror pain. The anterior cingulate cortex (ACC) is a first-order cortical region that responds to painful stimuli. In the present study, we systematically investigate and compare the neuroimmune changes in the bilateral ACC region using unilateral- (spared nerve injury, SNI) and mirror-(L5 ventral root transection, L5-VRT) pain models, aiming to explore the potential supraspinal neuroimmune mechanism underlying the mirror-image pain.