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Papers of the Week

2022 Jun 11

J Orthop Surg Res



Allogenic perinatal tissue for musculoskeletal regenerative medicine applications: a systematic review protocol.


Aratikatla A, Maffulli N, Rodriguez HC, Gupta M, Potty AG, El-Amin SF, Gupta A
J Orthop Surg Res. 2022 Jun 11; 17(1):307.
PMID: 35690774.


Musculoskeletal ailments impact the lives of millions of people, and at times necessitate surgery followed by physiotherapy, drug treatments, or immobilization. Regenerative musculoskeletal medicine has undergone enormous progress over the last few decades. Sources of tissues used for regenerative medicine purposes can be grouped into autologous or allogenic. Although autologous sources are promising, there is a wide range of limitations with the treatment, including the lack of randomized controlled studies for orthopaedic conditions, donor site morbidity, and highly variable outcomes for patients. Allogenic sources bypass some of these shortcomings and are a promising source for orthopaedic regenerative medicine applications.