I am a
Home I AM A Search Login

Papers of the Week

Papers: 11 Jun 2022 - 17 Jun 2022

2022 May 27

Int J Mol Sci



Expression and Biological Functions of miRNAs in Chronic Pain: A Review on Human Studies.


Sabina S, Panico A, Mincarone P, Leo C G, Garbarino S, Grassi T, Bagordo F, De Donno A, Scoditti E, Tumolo M R
Int J Mol Sci. 2022 May 27; 23(11).
PMID: 35682695.


Chronic pain is a major public health problem and an economic burden worldwide. However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are a class of small noncoding RNAs that post-transcriptionally regulate gene expression and serve key roles in physiological and pathological processes. This review aims to synthesize the human studies examining miRNA expression in the pathogenesis of chronic primary pain and chronic secondary pain. Additionally, to understand the potential pathophysiological impact of miRNAs in these conditions, an in silico analysis was performed to reveal the target genes and pathways involved in primary and secondary pain and their differential regulation in the different types of chronic pain. The findings, methodological issues and challenges of miRNA research in the pathophysiology of chronic pain are discussed. The available evidence suggests the potential role of miRNA in disease pathogenesis and possibly the pain process, eventually enabling this role to be exploited for pain monitoring and management.