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Papers of the Week

Papers: 11 Jun 2022 - 17 Jun 2022

2022 Jun 07

Brain Behav Immun

Sex, Pain, and the Microbiome: The Relationship between Baseline Gut Microbiota Composition, Gender and Somatic Pain in Healthy Individuals.


Caputi V, Bastiaanssen TFS, Peterson V, Sajjad J, Simons LP, Murphy A, Stanton C, McNamarad B, Shorten GD, Cryan JF, Mahony SMO'
Brain Behav Immun. 2022 Jun 07.
PMID: 35688340.


Relative to men, women present with pain conditions more commonly. Although consistent differences exist between men and women in terms of physiological pain sensitivity, the underlying mechanisms are incompletely understood and yet could inform the development of effective sex specific treatments for pain. The gut microbiota can modulate nervous system functioning, including pain signaling pathways. We hypothesized that the gut microbiota and critical components of the gut-brain axis might influence electrical pain thresholds. Further, we hypothesized that sex, menstrual cycle, and hormonal contraceptive use might account for inter-sex differences in pain perception.