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Papers of the Week

Papers: 4 Jun 2022 - 10 Jun 2022

Animal Studies

2022 Jun 08


Editor's Pick

Migraine and peripheral pain models show differential alterations in neuronal complexity.


Bertels Z, Mangutov E, Conway C, Siegersma K, Asif S, Shah P, Huck N, Tawfik V, Pradhan AA
Headache. 2022 Jun 08.
PMID: 35676889.


Our laboratory has recently shown that there is a decrease in neuronal complexity in head pain processing regions in mouse models of chronic migraine-associate pain and aura. Importantly, restoration of this neuronal complexity corresponds with anti-migraine effects of known and experimental pharmacotherapies. The objective of the current study was to expand this work and examine other brain regions involved with pain or emotional processing. We also investigated the generalizability of our findings by analyzing neuronal cytoarchitectural changes in a model of complex regional pain syndrome (CRPS), a peripheral pain disorder.