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Papers of the Week

Papers: 4 Jun 2022 - 10 Jun 2022

Human Studies

2022 Jun 07

BMC Anesthesiol



Dexmedetomidine prolongs the duration of local anesthetics when used as an adjuvant through both perineural and systemic mechanisms: a prospective randomized double-blinded trial.


Bao N, Shi K, Wu Y, He Y, Chen Z, Gao Y, Xia Y, Papadimos TJ, Wang Q, Zhou R
BMC Anesthesiol. 2022 Jun 07; 22(1):176.
PMID: 35672660.


To study the respective peripheral and systemic mechanisms of action of dexmedetomidine, as adjuvant to regional anesthesia, we compared dexmedetomidine added to ropivacaine for mid-forearm nerve blocks, to either systemic-only dexmedetomidine, and to a control with no dexmedetomidine.