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PLoS One



A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes.


Samuel JP, Wootton SH, Holder T, Molony D
PLoS One. 2022; 17(6):e0269387.
PMID: 35653405.


The single patient (n-of-1) trial can be used to resolve therapeutic uncertainty for the individual patient. Treatment alternatives are systematically tested against each other, generating patient-specific data used to inform an individualized treatment plan. We hypothesize that clinical decisions informed by n-of-1 trials improve patient outcomes compared to usual care. Our objective was to provide an overview of the clinical trial evidence on the effect of n-of-1 trials on clinical outcomes.