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Papers of the Week

Papers: 28 May 2022 - 3 Jun 2022

Animal Studies, Pharmacology/Drug Development

2022 Jun 01

BMC Pharmacol Toxicol



Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model.


Ruan D, Wang Y, Li S, Zhang C, Zheng W, Yu C
BMC Pharmacol Toxicol. 2022 Jun 01; 23(1):34.
PMID: 35642022.


Nalbuphine can relieve patients' inflammation response after surgery compared to other opioid drugs. However, its molecular mechanism has not been clear. Activation of NF-κB signaling pathway under oxidative stress and inflammation can maintain pain escalation.