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Papers of the Week


Papers: 28 May 2022 - 3 Jun 2022


Animal Studies, Pharmacology/Drug Development


2022 May 25


Eur J Pharmacol

Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder function in an in vivo rat model of chronic prostatitis.

Authors

Aydogdu O, Perez F, Aronsson P, Gocun P U, Carlsson T, Sandner P, Patel B, Winder M
Eur J Pharmacol. 2022 May 25:175052.
PMID: 35643304.

Abstract

Chronic pelvic pain syndrome (CPPS) is a common and bothersome condition for which no pharmacological treatment options with acceptable efficacy exist. The aim of this study was to investigate the effects of the soluble guanylate cyclase (sGC) activator BAY 60-2770 and the COX-2 inhibitor celecoxib on bladder function in a rat model of CPPS.